Izuchukwu E.N
Erik ten Hag, the manager of Man Utd, has made four changes from the team that played Southampton on Sunday and drew 0-0.
The main development is that Facundo Pellistri makes his debut out on the right flank as Antony is moved to the bench.
Raphael Varane is replaced at center back by captain Harry Maguire, and Tyrell Malacia starts ahead of Luke Shaw.
Fred is back in the starting line-up in place of Jadon Sancho, with Bruno Fernandes returning to a more familiar advanced role.
Wout Weghorst and Marcus Rashford make up the rest of the forward line while Casemiro starts again after being sent off at Old Trafford on Sunday.
Both Casemiro and Fernandes are one booking away from suspension in the Europa League.
Real Betis team news
Team to face Man Utd: Silva, Sabaly, Pezzella, Gonzalez, Vinicius, Rodriguez, Carvalho, Ruibal, Joaquin, Juanmi, Perez.
Subs: Bravo, Martin, Ruiz, Iglesias, Canales, Henrique, Jose, Guardardo, Rodri, Miranda, Garreta, Perez.
Man Utd team news
Team to face Real Betis: De Gea, Wan-Bissaka, Maguire, Martinez, Malacia; Casemiro, Fred; Fernandes, Pellistri, Weghorst, Rashford.
Subs: Heaton, Butland, Lindelogf, Sabitzer, Varane, Dalot, Shaw, Sancho, Elanga, McTominay.
